During the sixteenth century, when Seville was the point of departure and arrival of boats to the new American colonies, there were different private gardens in the city where newly arrived species from the New World were planted experimentally. So, the orchards of the son of Christopher Columbus, Hernando, or the physician Nicholas Monardes or the merchant Simon de Tovar, served as the first acclimatization gardens where it was checked whether the new plants could adapt to the conditions of the Iberian Peninsula. With people like Tovar one of the fathers of modern botany made contact, the Dutch Carolus Clusius, so as Tovar sent him descriptions and seeds of new species. After the death of Tovar, Clusius kept his relationship with Sevilla via letters with Juan de Castañeda, another physician who was a plant scholar, who was assisted by Rodrigo Zamorano, cosmographer, and teacher at the House of Trade, a place that worked then as a school of navigators among other things. Using his position as pilot examiner in the so called Indies race, Zamorano, and through him Castañeda, was bringing exotic plants from America. The contribution to botany of Castañeda is the number of New World plants on which it provided news or materials to Clusius, forty of which were able to be identified, including the 'mamones' along with Pita or Agave americana. Although, in fact, it would be the papaya the plant that here is called 'mamon', possibly also the tasty fruits of meliccoccus bijugatus came to Europe around this time of the late sixteenth when Castañeda and Zamorano were doing their work.