The Bigleaf Periwinkle is a very decorative ground cover plant, widely used in landscaping. Its name derives from the Latin vincere, meaning overcome, but also tie, an allusion to the function of its long flexible stems. Perhaps for this reason, the idea that it was a magic plant with which to prepare filters of love became popular. First described by the French Etienne Flacourt in 1645, governor of Madagascar by the French East India Company, the bigleaf periwinkle is nowadays well known because in the seventies compounds with significant anticancer virtues were found in it. Manhood has always sought in nature what they needed to calm their ills and recover from imbalances. It is estimated that two out of three drugs sold in pharmacies are of natural origin such as morphine (opium poppy), quinine (Cinchona bush), digitalis (foxglove grass) or acetilsalicic acid (white sauce), and in developing countries 80% of the population is treated directly with traditional remedies extracted from plants. In Seville, throughout its history, there were many doctors and scientists from different civilizations, who devoted themselves to this search. A striking case was, as already noted, the one of Nicholas of Monardes, who transformed his garden, where acclimating new plants from America, in a real laboratory for testing the properties and effects of plants on the human body.